Paclitaxel, Umuti usanzwe urwanya kanseri ukomoka kuri Taxus chinensis

Paclitaxel ni ikintu cyakuwe muri yew, gishobora guhagarika neza kanseri kandi ni imiti ikoreshwa cyane mu kurwanya anticancer ku isi.Mu myaka ya za 1960, abahanga mu bya shimi b'Abanyamerika batandukanije tagisi mu kibabi cya pasifika yew, uruganda rwa Taxus. Nyuma yimyaka irenga 20 ubushakashatsi ku mavuriro, inshinge ya mbere ya paclitaxel "Taxol" yatangijwe mu 1992. Kugeza ubu,paclitaxelni umwe mu miti izwi cyane yo kurwanya ibibyimba birwanya ibibyimba bifite akamaro keza.Bifite ibimenyetso biranga imikorere myiza, uburozi buke hamwe na spécran yagutse. Ifite ingaruka zigaragara zo kuvura kanseri yintanga, kanseri y'ibere, Melanoma mbi, kanseri y'ibihaha, kanseri ya prostate, ubwonko kanseri na kanseri yibara.

Ibisubizo byubushakashatsi bwubuvuzi byerekana ko, kuri ubu, kugurapaclitaxel APIsahanini biterwa no gukuramo ibihingwa bya Taxus chinensis hamwe na Semisynthesis ya chimique.Abashakashatsi ba siyansi bakusanya amashami n’ibibabi byahinzwe mu buryo bwa artificiel chinensis, gukoresha ibishishwa bya solvent, gukuramo ibyiciro bikomeye, gukuramo amazi ya Supercritical, gutandukanya membrane, gutandukanya chromatografique nubundi buryo bwo gutandukana no gukuramo gukuramo prursors isa nuburyo bwa paclitaxel, nka bacatine III, 10 deacetyl bacatine III, nibindi, hanyuma ukabona imiti myinshi ya paclitaxel ivura hakoreshejwe uburyo bwa chimique.

Dukurikije imibare y’abahanga, abarwayi ba kanseri bakeneye kurya garama zirenga 2 zapaclitaxelmuburyo bumwe bwo kuvura.Iyi miterere ya paclitaxel igomba gukurwa mubishishwa byibiti 4-8 byo mu gasozi bya Taxus chinensis bimaze imyaka irenga 50. Kuruhande rumwe, Taxus chinensis na paclitaxel ni gake, no kuri kurundi ruhande, hari ubuvuzi bukenewe cyane, buganisha ku giciro cyo hejuru cyibikoresho fatizo bya Taxus chinensis umwaka wose, kandi itangwa rikaba ridakenewe.

Ibisobanuro: Ingaruka zishoboka hamwe nibisabwa byavuzwe muriyi ngingo byose biva mubitabo biboneka kumugaragaro.

Gusoma kwagutse: Yunnan Hande Bio-tekinoloji ikora cyane cyane mu gucukura no guteza imbere tagisi.Ibicuruzwa byibanze ni Paclitaxel karemano, 10-DAB Semisynthesis Paclitaxel, 10-DABIII, docetaxel, cabataxel, nibindi Niba ukeneye kumenya ibijyanye na paclitaxel. ibikoresho fatizo, nyamuneka twumve neza.