Gutunganya umusaruro nubuhanga bwa Paclitaxel API

Paclitaxel nibiyobyabwenge bisanzwe bibaho bifite ibikorwa bikomeye byo kurwanya kanseri, bikoreshwa cyane mukuvura kanseri zitandukanye. Hamwe n’ubuvuzi bugenda bwiyongera, uburyo bwo gukora n’ikoranabuhanga byaYamazaki APInazo zikomeje gutera imbere.Iyi ngingo izerekana uburyo bwo gukora nubuhanga bwa Paclitaxel API muburyo burambuye.

I.Ibikoresho no Gukuramo Paclitaxel

Paclitaxel ikomoka cyane cyane kuri Taxus brevifolia, Taxus cuspidata, Taxus wallichiana nandi moko ya Taxus.Uburyo bwo gukuramo bukubiyemo ahanini gukuramo ibishishwa, gukuramo ultrasonic, gukuramo microwave, nibindi. Gukuramo ibishishwa nuburyo bukoreshwa cyane, ariko bufite ibibazo nkigihe cyo gukuramo igihe kirekire no gukoresha ibinini byinshi. Kubera iyo mpamvu, mu myaka yashize, abashakashatsi bakomeje kugerageza uburyo bushya bwo kuvoma, nka enzyme hydrolysis, gukuramo amazi ya supercritical fluid, nibindi, kugirango barusheho gukora neza no kwera.

II.Ibikorwa byo kubyara umusaruro wa Paclitaxel

Uburyo bwa fermentation yo gukora umusaruro wa Paclitaxel

Mu myaka yashize, uburyo bwa fermentation bwakozweho ubushakashatsi bwimbitse kugirango habeho umusaruro wa Paclitaxel.Ubu buryo bukoresha ikoranabuhanga rya fermentation ya mikorobe kugirango habeho Paclitaxel mu guhinga no gusembura selile ya Taxus.Ubwo buryo bufite ibyiza nkumusaruro muke muto, umusaruro mwinshi, nubuziranenge bwinshi.Nyamara , bisaba kunonosora imiterere ya fermentation no kwerekana imiterere itanga umusaruro mwinshi kugirango umusaruro unoze kandi ugabanye ibiciro.

Uburyo bwa synthesis ya chimique yo gukora umusaruro wa Paclitaxel

Sintezike ya chimique nubundi buryo bwingenzi bwo gukora umusaruro wa Paclitaxel.Ubu buryo bukoresha tekinoroji ya synthesis ya organic kugirango ihuze Paclitaxel ikoresheje inzira ya synthesis ya chimique.Nubwo ubu buryo bufite ibyiza nkumusaruro munini n’isuku ryinshi, bufite ibibi nkinzira ndende ya synthique na ikiguzi kinini, kigabanya imikoreshereze yacyo ifatika.

Gukomatanya kuvoma bisanzwe hamwe na synthesis ya chimique mugikorwa cyo gukora

Kugira ngo batsinde imbogamizi zuburyo bumwe bwo gukora, abashakashatsi barimo gukora ubushakashatsi ku guhuza ibimera bisanzwe hamwe na synthesis ya chimique mugikorwa cyo kubyaza umusaruro.Ubu buryo bwabanje gukuramo ibintu byabanjirije ibintu bya Paclitaxel mu bwoko bwa Taxus hakoreshejwe ibishishwa, hanyuma bikabihindura muri Paclitaxel hakoreshejwe synthesis. ikoranabuhanga.Ubu buryo bukomatanya ibyiza byo gukuramo kamere hamwe na synthesis ya chimique, bizamura umusaruro nubuziranenge, kandi bigabanya ibiciro byumusaruro.

III. Guhindura no Gutezimbere Icyerekezo Cyikoranabuhanga rya Paclitaxel

Kunoza uburyo bwo kuvoma no kweza: Gutezimbere uburyo bwikoranabuhanga bwo kuvoma neza kandi byangiza ibidukikije, nkumuti mushya, imisemburo ikomatanya, nibindi, kugirango tunonosore neza kandi byera bya Paclitaxel.

Kunonosora imiterere ya fermentation no gusuzuma ibintu bitanga umusaruro mwinshi: Kunonosora imiterere ya fermentation (nkibigize urwego ruciriritse, ubushyuhe, agaciro ka pH, nibindi.) No kwerekana umusaruro utanga umusaruro mwinshi kugirango wongere umusaruro nubuziranenge bwumusemburo wa Paclitaxel.

Kugabanya ibiciro byumusaruro: Gutezimbere ibikoresho bishya, kunoza imikorere yumusaruro, no kugera kumusaruro munini kugirango ugabanye umusaruro wa Paclitaxel no kuzamura isoko ryarwo.

Gushimangira kugenzura ubuziranenge: Gushiraho uburyo bunoze bwo kugenzura ubuziranenge bwo kugenzura neza ubwiza bw’ibikoresho fatizo, uburyo bwo kubyaza umusaruro, n’ibicuruzwa binyuze mu kugenzura ubuziranenge bukomeye no gupima isesengura kugira ngo ibicuruzwa n'umutekano bibe byiza.

Gutezimbere uburyo bushya: Gutezimbere uburyo bushya (nka nanomateriali, liposome formulaire, nibindi.) Kugirango tunoze bioavailable na efficacy ya Paclitaxel muri vivo hashingiwe kubibazo byayo byo kwa muganga.

Kwagura imirima ikoreshwa: Kongera kwagura imirima ya Paclitaxel irenze kuvura kanseri (nka anti-inflammatory, antioxidant effects), kugirango ikore ingaruka nini za farumasi nagaciro kayo.

IV.Umwanzuro n'ibiteganijwe

Hamwe niterambere ryiterambere rya siyanse nikoranabuhanga hamwe n’ubuvuzi bukeneweYamazaki API, uburyo bwo kubyaza umusaruro nubuhanga bwa Paclitaxel API nabwo bukomeje gutera imbere.Mu bihe biri imbere, abashakashatsi bazakomeza gushakisha uburyo bushya bwo kubyaza umusaruro nuburyo bwa tekiniki bwo kunoza umusaruro wa Paclitaxel, kugabanya ibiciro by’umusaruro, kwagura imirima yabyo, no gutanga umusanzu munini ku buzima bw'abantu.

Icyitonderwa: Ingaruka zishoboka hamwe nibisabwa bivugwa muriyi ngingo biva mubitabo byatangajwe kumugaragaro.