Gushakisha Kuramba: Inkomoko nshya kuri Paclitaxel

Paclitaxel niwo muti ukoreshwa cyane mu kuvura kanseri, ukomoka mu giti cya pasifika (Taxus brevifolia) .Nyamara, uburyo bwo gukura muri iki giti bwatumye ingaruka z’ibidukikije zidashoboka, bituma abahanga bashakisha amasoko arambye kugira ngo babone ibyo bakeneye. Iyi ngingo irasesengura inkomoko ya paclitaxel, ubundi buryo, niterambere rizaza.

Yamazakini imiti igabanya ubukana ikoreshwa mu kuvura ubwoko butandukanye bwa kanseri, harimo kanseri y'intanga, kanseri y'ibere, na kanseri y'ibihaha itari ntoya.Nyamara, uburyo bwambere bwo kuvoma bwashingiraga cyane cyane ku gusarura ibishishwa n'amababi by'igiti cya yew ya pasifika, biganisha kuri kugabanuka gukabije kwabaturage b’ibi biti.Ibi byazamuye impungenge z’ibidukikije, kuko ibi biti bikura buhoro kandi ntibikwiriye gusarurwa nini.

Kugira ngo iki kibazo gikemuke, abahanga bagiye bashakisha ubundi buryo nuburyo bwo kubona paclitaxel.Dore ubundi buryo bwakoreshwa ubu burimo kwigwa:

1.Taxus yunnanensis: Iki giti cya yew, kavukire mu Bushinwa, kirimo na paclitaxel.Abashakashatsi bagiye bashakisha uburyo bwo kuvana paclitaxel muri Taxus yunnanensis, ishobora gufasha kugabanya kwishingikiriza ku giti cyera cya pasifika.

2.Imisemburo ya Himiki: Abahanga bagiye bakora ubushakashatsi muburyo bwo guhuza imiti ya paclitaxel.Mu gihe ubu ari uburyo bufatika, akenshi burimo intambwe igoye ya synthesis kandi ihenze.

3.Fermentation: Gukoresha fermentation ya mikorobe kugirango ubyare paclitaxel nubundi buryo bwubushakashatsi.Ubu buryo butanga amasezerano yo kugabanya gushingira ku gukuramo ibimera.

4.Ibindi bimera: Usibye yew ya pasifika na Taxus yunnanensis, ibindi bimera birimo kwigwa kugirango hamenyekane niba paclitaxel ishobora kuvamo.

Mu gihe gushakisha amasoko arambye ya paclitaxel bikomeje, bifite akamaro gakomeye.Bishobora kugabanya umuvuduko w’abaturage b’ibiti by’ibiti bya pasifika, kubungabunga ibidukikije, no kwemeza ko abarwayi bakomeza kungukirwa n’iki kiyobyabwenge gikomeye cya antikanseri.Nyamara, ibishya byose uburyo bwo kubyaza umusaruro bugomba gukorerwa ubushakashatsi bukomeye bwa siyansi no kugenzurwa kugirango harebwe ubuziranenge n’umutekano w’ibiyobyabwenge.

Mu gusoza, gushakisha amasoko arambye yapaclitaxelni agace k’ubushakashatsi gafite ubushobozi bwo guteza imbere iterambere rirambye mu kuvura kanseri mu gihe cyo kubungabunga ibidukikije.Ubushakashatsi bwa siyansi n’udushya mu ikoranabuhanga bizakomeza kuduha ubundi buryo bwo gukemura ibibazo by’ubuvuzi.