Paclitaxel ni uruganda rusanzwe rwakuwe mu gihingwa cya yew, gifite ibikorwa bikomeye byo kurwanya ibibyimba. Kuva paclitaxel yatandukanijwe bwa mbere n’igishishwa cya pasifika yew mu 1971, ubushakashatsi bwayo mu bijyanye no kuvura kanseri bwashimishije cyane.Iyi ngingo izabikora shakisha byimbitse ingaruka zo kuvura zapaclitaxelku bwoko butandukanye bwa kanseri.
Imiterere n'imiterere ya paclitaxel
Paclitaxel ni urusobekerane rwa tetracyclic diterpenoid rufite imiterere yihariye yuburyo butatu, itanga urufatiro rwibikorwa byayo birwanya ibibyimba. Ifumbire ya molekile ni C47H51NO14, uburemere bwa molekile ni 807.9, kandi ni ifu yumuhondo yoroheje ya kirisiti yubushyuhe bwicyumba.
Uburyo bwo kurwanya kanseri yapaclitaxel
Uburyo bwo kurwanya kanseri ya paclitaxel bufitanye isano ahanini no kubuza tubuline depolymerisation n'ingaruka zayo mu kugabana ingirabuzimafatizo no gukwirakwira. By'umwihariko, paclitaxel irashobora guteza imbere microtubule polymerisation kandi ikabuza microtubule depolymerisation, bityo bikabangamira inzira isanzwe yo kugabana selile no gukwirakwira, biganisha ku bikorwa bisanzwe ku rupfu rw'akagari. Byongeye kandi, paclitaxel irashobora kandi gutera selile apoptose no kubuza ikibyimba angiogenez.
Ingaruka zo kuvura paclitaxel ku bwoko butandukanye bwa kanseri
1.Kanseri y'ibere: Ingaruka zo kuvura paclitaxel kuri kanseri y'ibere zamenyekanye cyane.Mu bushakashatsi bwakozwe ku barwayi ba kanseri y'ibere 45, paclitaxel ifatanije na chimiotherapie byatumye ibibyimba bigabanuka ku barwayi 41% kandi bivuze ko ubuzima bumaze amezi arenga 20.
2.Kanseri y'ibihaha itari ntoya: Kuri kanseri y'ibihaha itari ntoya, paclitaxel ihujwe n'imiti ya chimiotherapie ishingiye kuri platine irashobora guteza imbere ubuzima bw'abarwayi. Ubushakashatsi bwakozwe ku barwayi 36 barwaye kanseri y'ibihaha itari ntoya bwerekanye ko paclitaxel ifatanije na chimiotherapie yatumye habaho kubaho hagati y'amezi 12.
3. Kanseri y’intanga: Mu kuvura abarwayi ba kanseri y’intanga 70, paclitaxel ihujwe n’imiti ya chimiotherapie ishingiye kuri platine yagabanije ibibyimba ku barwayi 76%, naho imyaka ibiri yo kubaho igera kuri 38%.
4.Kanseri ya Esophageal: Mu kuvura abarwayi 40 barwaye kanseri yo mu nda, paclitaxel ifatanije na radiotherapi yagabanije ibibyimba ku barwayi 85%, kandi umwaka umwe wo kubaho wageze kuri 70%.
5.Kanseri yo mu gifu: Mu kuvura kanseri yo mu gifu, paclitaxel ifatanije na fluorouracil irashobora kuzamura cyane ubuzima bw'abarwayi.Mu bushakashatsi bwakozwe ku barwayi 50 barwaye kanseri yo mu nda,paclitaxelhamwe na chimiotherapie byatumye habaho kubaho hagati y'amezi 15.
6.Kanseri yibara: Mu kuvura abarwayi 30 ba kanseri yibara, paclitaxel ihujwe na oxaliplatine yagabanije ibibyimba ku barwayi 80%, naho imyaka ibiri yo kubaho igera kuri 40%.
7.Kanseri y'ubuzima: Nubwo ingaruka za paclitaxel monotherapy kuri kanseri y'umwijima ari nkeya, guhuza indi miti ya chimiotherapie nka cisplatine na fluorouracil 5 bishobora kuzamura imibereho y'abarwayi.Ubushakashatsi bwakozwe ku barwayi 40 barwaye kanseri y'umwijima bwerekanye ko paclitaxel ihuriweho hamwe na chimiotherapie byatumye habaho kubaho hagati y'amezi 9.
8.Kanseri y'impyiko: Mu kuvura kanseri y'impyiko, paclitaxel ifatanije n'imiti ikingira indwara nka interferon-alpha irashobora guteza imbere ubuzima bw'abarwayi.Ubushakashatsi bwakozwe ku barwayi 50 barwaye kanseri y'impyiko bwerekanye ko paclitaxel ifatanije na immunotherapie byatumye habaho kubaho hagati mu buzima Amezi 24.
9.Leukemia: Mu kuvura acute myeloid leukemia, paclitaxel ihujwe n’imiti ya chimiotherapie nka cytarabine irashobora gutuma abarwayi bagera ku kigero cyo hejuru cyo kwandura.Ubushakashatsi bwakozwe ku barwayi 30 barwaye leukemia ikaze bwerekanye ko paclitaxel ifatanije na chimiotherapie byavuyemo igisubizo cyuzuye muri 80% by'abarwayi.
10. mubisubizo byuzuye muri 85% byabarwayi.
Umwanzuro
Muri make, paclitaxel yerekanye akamaro kanini mukuvura ubwoko butandukanye bwa kanseri.Nyamara, ni ngombwa kumenya ko uburyo bwo kuvura butandukanye kuri buri bwoko bwa kanseri kandi akenshi busabwa bufatanije nibindi biyobyabwenge. Byongeye kandi, bitewe na bigoye kandi bitandukanye bitandukanye na kanseri, gahunda yo kuvura igomba kuba yihariye kuri buri murwayi.Ubushakashatsi buzaza bugomba kurushaho gushakisha ubushobozi bwa paclitaxel mu kuvura kanseri no kunoza imikoreshereze yabwo.
Icyitonderwa: Inyungu zishobora gukoreshwa muri iyi ngingo zikomoka mubitabo byatangajwe.
Igihe cyo kohereza: Ugushyingo-17-2023