Uburyo budasanzwe bwo kurwanya ibibyimba bya Paclitaxel

Paclitaxel ni imiti isanzwe irwanya kanseri yabonetse muri iki gihe.Bikoreshwa cyane mu kuvura kanseri y’intanga ngore, kanseri y'ibere, kanseri y'ibihaha, ibibyimba byo mu mutwe no mu ijosi, kanseri yo mu nda, kanseri yo mu gifu na sarcoma yoroheje.Yamazakiyashimishije cyane abahanga kubera imiterere y’imiti igoye kandi yubuhanga, uburyo bwihariye bwibinyabuzima bwibikorwa, ibikorwa bya anticancer byizewe, hamwe nubuke bukabije bwumutungo. Dukurikije imibare, laboratoire zirenga 30 zikomeye kwisi zakoze ubushakashatsi kuri Total synthesis ya paclitaxel, kandi amarushanwa arakaze cyane, akaba yarabaye intandaro ya chimie ngengabihe ya chimique mu mpera z'ikinyejana cya 20.

Uburyo budasanzwe bwo kurwanya ibibyimba bya paclitaxel

Paclitaxel irashobora gutuma Tubulin na Tubulin dimer igizwe na microtubules itakaza Dynamic equilibrium, itera kandi igateza imbere polymerisation ya Tubulin, iteraniro rya microtubule, kandi ikarinda depolymerisation, kugirango ihagarike microtubules kandi ibuze Mitose ya selile kanseri kandi itume apoptose ikwirakwira neza. selile no kugira uruhare mu kurwanya kanseri.

Mubyukuri, Tubulin, ifitanye isano rya hafi na selile Mitose, ibaho hafi yisi yose mungirangingo zose za eukaryotic.Birashobora polymerize muri microtubules ku buryo budasubirwaho. Gutandukana kwa chromosome bisaba ubufasha bwiyi microtubules. Nyuma ya Mitose, izo microtubules zongeye kwangirika muri Tubulin. Igihe gito gusenyuka ku nyundo nka microtubules birashobora kwica cyane ingirabuzimafatizo zifite amacakubiri adasanzwe.Imiti imwe n'imwe ikomeye yo kurwanya kanseri, nka colchicine, Vinblastine, Vincristine, igira uruhare mu kurwanya ibibyimba mu kubuza Tubulin kongera gukora polymerisime.

Bitandukanye no kurwanya Mitose n'imiti irwanya ibibyimba,paclitaxelniwo muti wambere wabonetse ushobora gukorana na polymer ya Tubulin, ni ukuvuga, ukora muguhuza cyane na microtubules kugirango itekane.Mu gihe kimwe, usanga paclitaxel yerekana ingaruka nziza kumasemburo atandukanye yibibyimba bikomeye.Iyi nshya kuvumbura byakuruye abahanga mubuzima bwibinyabuzima gukoreshapaclitaxelnkigikoresho cyubushakashatsi muri biomedicine, gushakisha imirima itazwi yibikorwa bya selile no kuvumbura uburyo bushya bwimiti igabanya ubukana.

Ibisobanuro: Ingaruka zishoboka hamwe nibisabwa byavuzwe muriyi ngingo byose biva mubitabo biboneka kumugaragaro.

Yunnan Hande Bio-tekinike imaze imyaka 28 yibanda ku musaruro wa paclitaxel.Ni uruganda rwigenga rw’ibikoresho fatizo bya paclitaxel, byemejwe n’inzego z’igihugu zishinzwe kugenzura nka FDA muri Amerika, EDQM i Burayi, TGA muri Ositaraliya, CFDA mu Bushinwa, Ubuhinde, n’Ubuyapani.Yunnan Handepaclitaxeliraboneka mububiko kandi igurishwa muburyo butaziguye nababikora.Murakaza neza kubaza.