Amakuru y'ibicuruzwa
Artemisinin numuti ufite ingaruka nziza mukuvura malariya.Ni sesquiterpene lactone hamwe nitsinda rya peroxide yakuwe muri Artemisia annua.Ifite ibiranga imikorere myiza, ingaruka zihuse, gukuraho ubushyuhe no kugabanya ubushyuhe bwimpeshyi, kugabanya ubushyuhe buke, kwica protozoa nuburozi buke.Kugeza ubu, imikorere ya artemisinin ishingiye ku buvuzi hamwe (ACT) mu kuvura malariya imaze kugera kuri 90% ku isi yose.Yakoreshejwe cyane mukuvura malariya kwisi yose.
1 unction Imikorere
1. Kurwanya malariya
Malariya (bakunze kwita indwara ya pendulum ikonje na fever) ni udukoko twanduye.Nindwara yandura iterwa no kurumwa numubiri wabantu wanduye Plasmodium.Irashobora kugaragara hepatosplenomegaly na anemia nyuma yibitero byigihe kirekire.Artemisinin yagize uruhare mu kuvura malariya ku rugero runaka.Inkunga ya peroxide mu miterere ya artemisinin ni okiside kandi ni itsinda ryingenzi mu kurwanya malariya.Uburyo bwibikorwa nuko itsinda ryubuntu ryakozwe na artemisinin muri vivo ihuza poroteyine ya Plasmodium falciparum kandi igahindura imiterere ya selile ya Plasmodium falciparum.Nyuma ya radicals yubusa ihujwe na proteine ya Plasmodium, membrane ya bilayeri ya mitochondria izabyimba kandi ivunike, amaherezo igwe, bikaviramo gusenya imiterere yimikorere nimikorere ya Plasmodium, na chromatine muri nucleus nayo izagira ingaruka kuri bamwe. urugero.
2. Kurwanya
Ikibyimba kibi nicyo cyica cya mbere kibangamiye ubuzima bwabantu.Niba itavuwe mugihe, bizabangamira umutekano wubuzima.Mu bushakashatsi bwa vitro bwerekanye ko igipimo runaka cya artemisinine gishobora gutera apoptose yubwoko butandukanye bwa kanseri, nka selile hepatoma, kanseri yamabere, kanseri yinkondo y'umura nibindi, kandi bikabuza cyane gukura kwa kanseri.Byagaragaye ko artemisinin ishobora kugenga imvugo ya cyclin mu ngirabuzimafatizo y'ibibyimba, ikongera ingaruka za CKIs kandi bigatuma ifata ingirabuzimafatizo zifata;Cyangwa biganisha kuri apoptose no kubuza ikibyimba angiogenez kugirango wirinde kubaho no gukura kw'ibibyimba.Artemisinin ikoreshwa mu kuvura indwara ya leukemia ikora ku ngirabuzimafatizo ya selile ya leukemia, ikongerera ubushobozi bwa membrane kandi igahindura umuvuduko wa osmotic, bigatuma kwiyongera kwa calcium mu ngirabuzimafatizo, kugira ngo ikore calpain, itume ingirabuzimafatizo zayo zibyimba no kumena, kwihutisha kurekura ibintu bya apoptotique no kongera umuvuduko wa apoptose.
3. Kuvura hypertension yimpyisi
Indwara ya hypertension (PAH) ni imiterere ya patrophysiologique irangwa no kuvugurura imiyoboro y'amaraso no kuzamuka k'umuvuduko w'amaraso uva ku mipaka runaka.Birashobora kuba ingorabahizi cyangwa syndrome.Artemisinin ikoreshwa mu kuvura umuvuduko ukabije w'amaraso: irashobora kugabanya umuvuduko w'amaraso no kunoza ibimenyetso ku barwayi barwaye PAH mu kuruhura imiyoboro y'amaraso.Zaiman n'abandi.Basanze artemisinin igira ingaruka zo kurwanya inflammatory.Artemisinin nibintu byayo byingenzi birashobora kubuza ibintu bitandukanye gutwika, kandi birashobora no kubuza umusaruro wa aside nitide nabunzi batera umuriro;Artemisinin igira ingaruka zo gukingira;Feng Yibai n'abandi basanze artemisinin ishobora kubuza ikwirakwizwa ry'uturemangingo twa endoteliyale y'amaraso hamwe n'imitsi yoroheje y'imitsi, hanyuma ikagira uruhare runini mu kuvura PAH;Artemisinin irashobora guhagarika ibikorwa bya matrix metalloproteinase, bityo ikabuza kuvugurura imitsi yimitsi;Artemisinin irashobora guhagarika imvugo ya cytokine ijyanye na PAH kandi ikarushaho kongera imbaraga zo guhindura imitekerereze ya artemisinin.
4. Kugena ubudahangarwa bw'umubiri
Byagaragaye ko igipimo cya artemisinin n'ibiyikomokaho bishobora kurushaho kubuza T lymphocyte mitogen kandi bigatera ikwirakwizwa rya lymphocytes yimbeba idafite cytotoxicity.Ubu bushakashatsi bufite agaciro keza ko kuvura indwara ya lymphocyte T yanduye indwara ziterwa na autoimmune.Artemisia annua ikirahuri vinegere irashobora kongera ubudahangarwa budasanzwe no kunoza ibikorwa byuzuzanya bya serumu yimbeba.Dihydroartemisinin irashobora guhagarika mu buryo butaziguye ikwirakwizwa rya lymphocytes B, kugabanya ururenda rwa autoantibodies na B lymphocytes B, kugabanya ubudahangarwa bw’umubiri, kubuza ubudahangarwa bw’urwenya no kugabanya imiterere y’umubiri.
5. Antifungal
Ingaruka ya antifungal ya artemisinin nayo ituma artemisinin yerekana ibikorwa bimwe na bimwe bya antibacterial.Ubushakashatsi bwemeje ko ifu isigaye hamwe n’amazi ya artemisinine yagize ingaruka zikomeye za antibacterial kuri anthrax, Staphylococcus epidermidis, catarrhalis na diphtheria, ndetse ikagira n'ingaruka zimwe na zimwe za antibacterial ku gituntu, Pseudomonas aeruginosa, Staphylococcus aureus na dysentery bacilli.
2 field Umwanya wo gusaba
Artemisia annua ikoreshwa nk'imiti igabanya ubukana.Gukoresha kwa muganga byagaragaje ko artemisinin n'ibiyikomokaho bigira ingaruka zidasanzwe kuri Plasmodium falciparum na Plasmodium falciparum, cyane cyane Artemisia annua a, ifite ingaruka zikomeye kuruta iyindi miti ya artemisinine yica clone zo mu nda za Plasmodium falciparum.
Ibipimo byibicuruzwa
| UMWUGA W'ISHYAKA | |
| izina RY'IGICURUZWA | Artemisinin |
| CAS | 63968-64-9 |
| Imiti yimiti | C15H22O5 |
| Brand | Hande |
| Muruganda | Yunnan Hande Bio-Tech Co, Ltd. |
| Country | Kunming,China |
| Hashyizweho | 1993 |
| BAMAKURU ASIC | |
| Synonyme | 3,12-epoxy-12h-pyranol (4,3-j) -1,2-benzodioxepin-10 (3h) -umuntu umwe, octahydro-3,6,9-tri;artemisiaannual., ikuramo; huanghuahaosu;octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano (4,3-j) -1,2-benzodioxepin-10 (; qinghausau; qinghausu; QHS; ARTEMISININ99% |
| Imiterere |  |
| Ibiro | 282.34 |
| HS Kode | N / A. |
| UbwizaSpecification | Ibisobanuro bya sosiyete |
| Certificates | N / A. |
| Suzuma | Guhitamo ukurikije ibyo abakiriya bakeneye |
| Kugaragara | Kirisiti idafite amabara |
| Uburyo bwo gukuramo | Artemisia annua |
| Ubushobozi bwa buri mwaka | Guhitamo ukurikije ibyo abakiriya bakeneye |
| Amapaki | Guhitamo ukurikije ibyo abakiriya bakeneye |
| Uburyo bwo Kwipimisha | N / A. |
| Ibikoresho | Kugwizaubwikorezis |
| PaymentTerms | T / T, D / P, D / A. |
| Other | Emera ubugenzuzi bwabakiriya igihe cyose;Fasha abakiriya kwiyandikisha kugenga. |
Tanga ibicuruzwa
1.Ibicuruzwa byose byagurishijwe nisosiyete ni ibikoresho byarangije igice.Ibicuruzwa byibanda cyane cyane kubabikora bafite ibyangombwa byo gukora, kandi ibikoresho fatizo ntabwo aribicuruzwa byanyuma.
2.Ibishobora kuba byiza nibisabwa mugutangiza byose biva mubitabo byatangajwe.Umuntu ku giti cye ntabwo asaba gukoresha mu buryo butaziguye, kandi kugura kugiti cye byanze.
3.Amashusho nibicuruzwa byamakuru kururu rubuga bireba gusa, kandi ibicuruzwa nyirizina bizatsinda.
