10-DAB Semi-Synthetic Paclitaxel: Intambwe ikomeye mu rwego rwo guhuza ibiyobyabwenge

Paclitaxel numuti wingenzi ukoreshwa cyane mukuvura kanseri, ariko inkomoko yabyo ni mike.Mu rwego rwo guhaza paclitaxel ikenewe ku isoko rya farumasi, abahanga bakoze ubushakashatsi bwimbitse, uburyo bwa sintetike bukoreshwa muburyo bukomeye bwo gukora.Iyi ngingo izerekana inzira yo guhuza igice cya paclitaxel kuva 10-deacetylbaccatin III (10-DAB) kandi ishimangire akamaro kayo murwego rwo guhuza ibiyobyabwenge.

Paclitaxel, ubusanzwe yitandukanije nigishishwa cyigiti cya pasifika ya pasifika, azwi cyane kubera kurwanya kanseri.Nyamara, pasifike yew ni umutungo kamere utagira ingano, udahagije kugirango ubone ubuvuzi bugezweho bwa paclitaxel.Iterambere ryuburyo bwa sintetike ryatumye umusaruro munini wa paclitaxel ushoboka, hamwe na 10-deacetylbaccatin III ari intera ikomeye.

Gutegura 10-DAB muri Semi-Synthetic Paclitaxel:

10-DAB ni intera ikomeye hagati yinzira ya sintetike yinzira igana paclitaxel kandi isaba intambwe nyinshi zo kuyitegura.Mubisanzwe, synthesis ya 10-DAB itangirana nibisanzwe bya paclitaxel, taxuyunnanine C, ikomoka kuri baccatine III.Baccatin III yabanje gucibwa kugirango itange 10-deacetylbaccatin III.Ibikurikira, 10-deacetylbaccatin III ihura nibisubizo byinshi, harimo hydrogenation, gusimburwa, epoxidation, hydrolysis, nibindi byinshi, amaherezo ihinduka 10-DAB.

Gusaba 10-DAB muri Semi-Synthetic Paclitaxel:

Synthesis ya 10-DAB yafunguye inzira nshya ya kimwe cya kabiri cya synthesis ya paclitaxel, itanga iterambere rirambye mu gukora ibiyobyabwenge.Paclitaxel ni imiti yagutse ya anticancer ikoreshwa mu kuvura ubwoko butandukanye bwa kanseri, harimo kanseri y'intanga, amabere, na kanseri y'ibihaha.Inzira ya sintetike igabanya ikiguzi cyo gukora ibiyobyabwenge, bigatuma ubu buryo bwo kuvura bworohereza abarwayi.

Umwanzuro:

Uburyo bwo guhuza igice cya paclitaxel kuva 10-DAB bwageze ku ntsinzi igaragara mubijyanye no guhuza ibiyobyabwenge.Ntabwo ikemura gusa ikibazo cyamasoko make ya paclitaxel ahubwo inazamura umusaruro kandi urambye.Iri koranabuhanga ryerekana intambwe igaragara mu gukora imiti igabanya ubukana kandi isezeranya ko hazakomeza gutera imbere mu buvuzi mu kurwanya indwara zikomeye nka kanseri.Mu bihe biri imbere, abashakashatsi bazakomeza kunonosora uburyo bwo guhuza uburyo bwo kunoza imikorere no kugabanya ibiciro, amaherezo bikagirira akamaro abarwayi benshi.

Icyitonderwa: Inyungu nibisabwa byavuzwe muriki kiganiro bishingiye kubitabo biboneka kumugaragaro.

Ibindi bisomwa: Yunnan Hande Biotech Co., Ltd., yibanda ku myaka 26 yibanda ku musaruro wa paclitaxel, ni uruganda rwemewe ku isi hose rukora uruganda rukora imiti ikomoka ku bimera paclitaxel ikomoka ku bimera, byemewe n’ibigo bishinzwe kugenzura nka Amerika FDA, EDQM yo mu Burayi. , Ositaraliya TGA, Ubushinwa CFDA, Ubuhinde, Ubuyapani, n'abandi.Yunnan Hande Paclitaxel, iboneka mububiko, igurishwa neza nuwabikoze.Nyamuneka nyamuneka guhamagara kuri +86 18187887160 (WhatsApp).