Imiterere yimiti nibikorwa bya farumasi ya paclitaxel

Paclitaxel (Paclitaxel) ni imiti isanzwe ya antikanseri ikurwa mu gihingwa cya yew, gifite imiterere yihariye y’imiti n'ingaruka za farumasi.Kuva paclitaxel yavumburwa mu 1971, ikoreshwa ryamavuriro ryageze ku bisubizo bitangaje.Muri iyi nyandiko, imiterere yimiti nibikorwa bya farumasi yapaclitaxelbizaganirwaho.

Imiterere yimiti ya paclitaxel

Imiterere yimiti ya paclitaxel iraruhije, igizwe nuburyo butandukanye bwimpeta, harimo imiterere ya diterpenoid yibanze, kikaba ari igice cyingenzi cyingaruka zo kurwanya kanseri ya paclitaxel.Molekile ya Paclitaxel nayo irimo amatsinda ya hydroxyl na ketone, kandi aho numubare wamatsinda bigena ibikorwa byihariye bya farumasi.

Ingaruka za farumasi ya paclitaxel

1. Microtubule stabilisation: Paclitaxel irashobora guteza imbere polymerisation ya microtubules no guhagarika microtubules ya polymerized, nuburyo bukuru bwingaruka za anticancer.Microtubules igira uruhare runini mu kugabana ingirabuzimafatizo, kandi paclitaxel ibuza gukura kw'ibibyimba mu guhagarika microtubules no gukumira amacakubiri.

2, itera gufata ingirabuzimafatizo: paclitaxel irashobora kandi gutuma ingirabuzimafatizo zifatwa, kugirango selile zidashobora gukomeza gucamo ibice no kwiyongera.Ubu ni ubundi buryo bwingenzi bwingaruka za anticancer.

3, gutera apoptose: paclitaxel irashobora gutuma imvugo y'abunzi benshi bashyigikira apoptose, yihutisha inzira ya apoptose ya selile kanseri.

4, kugenga abunzi barwanya apoptotique: paclitaxel irashobora kandi kugenga ibikorwa byabunzi barwanya apoptotique kugirango bahuze inzira ya apoptose no gukwirakwizwa.

Umwanzuro

Paclitaxel ni ubwoko bwimiti igabanya ubukana ifite imiterere yihariye yimiti nibikorwa bya farumasi.Irashobora guhagarika neza imikurire yikibyimba iteza imbere microtubule polymerisation, igahindura microtubules ya polymerized, itera gufatwa kwingirabuzimafatizo no gutera apoptose selile.Nyamara, uburozi n'ingaruka za paclitaxel nabyo birahangayikishijwe no kuvura.Ubundi bushakashatsi no gusobanukirwa ningaruka za farumasi ya paclitaxel bizafasha kunoza imikoreshereze yubuvuzi, kunoza imikorere yubuvuzi, no kugabanya ingaruka.

Ibizaza

Nubwo ikoreshwa rya clinique ya paclitaxel ryageze ku bisubizo bitangaje, ikibazo cyumutungo muke wacyo hamwe no gutanga ibintu biracyahari.Kubwibyo, abahanga mubijyanye na biologiya ya sintetike na chimie yubuvuzi barimo gukora kugirango bashake ubundi buryo bwa paclitaxel kugirango bakemure ibibazo bitangwa no kugabanya ibiciro byumusaruro.Mubyongeyeho, ubushakashatsi ku ngaruka za farumasi yapaclitaxelbizafasha kandi kuvumbura ingamba zifatika zo kuvura ubwoko bwa kanseri zitandukanye.

Mu bushakashatsi bwibanze nubushakashatsi bwamavuriro, guhuza paclitaxel nindi miti igabanya ubukana byagaragaje ibyiringiro.Muguhuza paclitaxel nindi miti, imikorere yubuvuzi irashobora kongererwa imbaraga no kwigaragaza kugabanuka.Mu bihe biri imbere, hamwe no kumenyekanisha ubuvuzi bwuzuye hamwe n’ibitekerezo by’ubuvuzi byihariye, ubushakashatsi no gusobanukirwa n’ingaruka za farumasi ya paclitaxel bizarushaho kuba byimbitse, kandi hazatangwa gahunda zuzuye zo kuvura abarwayi ba kanseri.

Muri rusange, paclitaxel ni imiti isanzwe ya anticancer ifite imiterere yihariye yimiti ningaruka za farumasi.Hamwe niterambere rihoraho rya siyanse nikoranabuhanga hamwe nubushakashatsi bwimbitse, turategerejepaclitaxelkugira uruhare runini mu kuvura kanseri zitandukanye mu bihe biri imbere, bizana ibisubizo byiza byo kuvura n’ubuzima bwiza ku barwayi.

Icyitonderwa: Inyungu zishobora gukoreshwa muri iyi ngingo zikomoka mubitabo byatangajwe.