Itandukaniro nibyiza hagati ya paclitaxel karemano na kimwe cya kabiri

Paclitaxel ni imiti ikomeye ya antikanseri, kandi imiterere yihariye n'ibikorwa by’ibinyabuzima byashimishije abahanga mu bya siyansi.Nkurikije inkomoko yabyo ndetse nuburyo bwo kuyitegura, paclitaxel irashobora kugabanywamo paclitaxel karemano na paclitaxel igice cya synthique.Iyi ngingo izaganira ku itandukaniro ninyungu. ya byombi.

Inkomoko nuburyo bwo gutegura

Paclitaxel.

Semi-synthique paclitaxel.

Imiterere yimiti

Nubwo paclitaxel karemano na paclitaxel igice cya sintetike itandukanye gato mumiterere yimiti, imiterere yabyo ni imwe, kandi byombi ni diterpenoid alkaloide.Iyi miterere idasanzwe ibaha ibikorwa biologiya bihuriweho.

Igikorwa cyibinyabuzima ningirakamaro

Paclitaxel naturel: Mubikorwa byubuvuzi, paclitaxel karemano yagaragaye ko ifite ingaruka zikomeye zo kuvura kanseri zitandukanye, zirimo kanseri yamabere, kanseri yintanga, kanseri zimwe na zimwe zo mumutwe no mu ijosi, na kanseri yibihaha. Igikorwa cya anticancer ahanini ni ukubuza polymerisation ya tubuline no gusenya urusobe rwa microtubule, bityo bikabuza ikwirakwizwa ry'uturemangingo no gutera apoptose ya selile.

Semi-synthique paclitaxel: Semi-synthique paclitaxel isa ningirakamaro mubikorwa bya paclitaxel karemano kandi ifite ibikorwa bya anticancer.Mass umusaruro mwinshi wa paclitaxel igice cya kabiri gishobora kongera ivuriro kandi bigatanga uburyo bwinshi bwo kuvura abarwayi ba kanseri.

Ingaruka mbi

Paclitaxel naturel: Uburozi bwa paclitaxel karemano ni buke, ariko burashobora gutera ingaruka mbi zimwe na zimwe, nka allergie reaction, guhagarika amagufwa hamwe nuburozi bwumutima.

Semi-sintetike paclitaxel: Ingaruka mbi za paclitaxel igice cya sintetike isa niza paclitaxel karemano.Bombi bakeneye imiti ifatika ishingiye kumiterere yabantu hamwe nibyifuzo byabaganga kugirango bagabanye ingaruka ziterwa ningaruka mbi.

Iterambere ry'ejo hazaza

Hamwe niterambere ryiterambere rya siyansi nikoranabuhanga, ubushakashatsi kuri paclitaxel nabwo buragenda bwiyongera.Mu gihe kizaza, abahanga bazakora ibishoboka kugirango bashakishe uburyo bunoze bwo guhuza paclitaxel kugirango barusheho kunoza imikorere y’umusaruro no kunoza imikorere y’amavuriro.Mu gihe kimwe, hamwe iterambere rya tekinoloji igenda igaragara nka injeniyeri yubuvuzi nubuvuzi bwakagari, ingamba zo kuvura yihariye ya paclitaxel nabyo bizashoboka, bityo biha abarwayi ba kanseri uburyo bwiza bwo kuvura kandi bunoze.

Umwanzuro

Byombipaclitaxelnaigice cya sintetike paclitaxelbafite ibikorwa bya anticancer mubikorwa byubuvuzi.Nubwo inkomoko yabyo nuburyo bwo gutegura bitandukanye, basangiye ibintu muburyo bwimiti, ibikorwa byibinyabuzima na farumasi. Umusaruro munini wa paclitaxel igice cya sintetike urashobora kongera ivuriro, mugihe paclitaxel isanzwe ifite a Ubushobozi bukomeye buturuka.Mu bushakashatsi buzaza, abahanga bazakomeza gushakisha uburyo bwibinyabuzima bwibikorwa ndetse n’ahantu hakoreshwa paclitaxel kugirango bazane ibyiringiro byo kuvura abarwayi ba kanseri.

Icyitonderwa: Inyungu zishobora gukoreshwa muri iyi ngingo zikomoka mubitabo byatangajwe.