Nigute paclitaxel ya Semi-synthique ikorwa?

Paclitaxel, imiti isanzwe irwanya kanseri, ikurwa cyane muri Taxus chinensis.Yakoreshejwe cyane mu kuvura kanseri y'ibere, kanseri y'intanga, ndetse na kanseri yo mu mutwe no mu ijosi na kanseri y'ibihaha mu mavuriro.Paclitaxel igabanyijemo kamerepaclitaxelnaSemi-synthique paclitaxel.Hepfo, reka turebe uko Semi-synthique paclitaxel ikorwa.

Kubera ko paclitaxel isanzwe ikurwa muri Taxus chinensis ifite amasoko make, kandi imikurire yikura rya chinensis ya Taxus karemano ni ndende, igishishwa cya 13,6 kg gusa gishobora gukuramo 1g ya paclitaxel, kandi bifata ibiti bya tagisi 3 kugeza 12 bifite amateka yimyaka irenga 100. kuvura umurwayi wa kanseri yintanga, kubura igihe kirekire kubitangwa nigiciro kinini bituma tekinoroji yubukorikori ya paclitaxel itera imbere byihuse.

Nkibintu byakuwe mu bimera karemano, paclitaxel ifite imiterere igoye.Nyamara, kugirango bakemure ikibazo cyibura ryibikoresho fatizo, abahanga mu bya shimi baturutse hirya no hino ku isi biga synthesis ya paclitaxel.Mu gihe umuhanga mu bya shimi w’umufaransa yatandukanije ibintu byitwa10-DABuhereye ku bibabi bya chinensis yo mu Bwongereza, imiterere yabyo yari imeze cyane nk'iya paclitaxel, kandi ibiyirimo byari byinshi.Amababi yari ashya cyane kuruta ibishishwa n'amashami, kandi ntibyangiritse cyane kuri Taxin chinensis.

Binyuze mu mbaraga zidacogora z'abahanga, uburyo bwaSemi-synthique paclitaxelamaherezo yaratejwe imbere, kandi ntibikiri ngombwa kugabanya imisoro ya Taxus chinensis kugirango iyikuremo.Noneho, mu kwiga imiterere ya paclitaxel, hateguwe indi miti yimiti nka docetaxel na albumin paclitaxel, izana imiti myinshi ivura abarwayi ba kanseri.

Ibisobanuro: Ingaruka zishoboka hamwe nibisabwa byavuzwe muriyi ngingo byose biva mubitabo biboneka kumugaragaro.

Gusoma kwagutse: Hande Bio-tekinoroji ikora cyane cyane mugukuramo no guteza imbere tagisi.Ibicuruzwa byingenzi ni paclitaxel karemano, 10-DAB Semi-synthique paclitaxel, 10-DABIII, docetaxel, cabataxel, nibindi Niba ukeneye kumenya ibya paclitaxel ishingiye kuri API, nyamuneka twandikire.