Paclitaxel naturel: imiti igabanya ubukana bwa anticancer

Paclitaxel, imiti isanzwe igabanya ubukana hamwe na formula C47H51NO14, yakoreshejwe cyane mu kuvura kanseri y'ibere, kanseri y'intanga ndetse na kanseri zimwe na zimwe zo mu mutwe, mu ijosi no mu bihaha.Nka diterpenoid alkaloide hamwe nibikorwa bya anticancer,paclitaxelyatoneshejwe cyane naba botaniste, abahanga mu bya shimi, abahanga mu bya farumasi naba biyolojiya y’ibinyabuzima bitewe n’imiterere y’imiti n’imiterere y’imiti, ibikorwa byinshi kandi by’ibinyabuzima, uburyo bushya kandi budasanzwe bw’ibikorwa, hamwe n’umutungo kamere muke, bituma uba inyenyeri n’ubushakashatsi bwibanze kuri anticancer muri igice cya kabiri cy'ikinyejana cya 20.

Uburyo bwibikorwa bya paclitaxel

Paclitaxel ibuza ikwirakwizwa rya kanseri ya kanseri ahanini itera gufata ingirabuzimafatizo no guteza impanuka za mitoto.Imiterere yacyo nuburyo bugoye bwa chimique itanga uburyo bwihariye bwibinyabuzima bwibikorwa.YamazakiIrashobora guhagarika ikwirakwizwa rya selile muguhagarika polymerisation ya tubuline no gusenya urusobe rwa microtubule.Byongeye kandi, paclitaxel irashobora kandi gutuma imvugo y'abunzi bashyigikira apoptotique ikanagenzura ibikorwa by'abunzi barwanya apoptotique, bityo bigatuma apoptose ya selile ya kanseri.

Igikorwa cyo kurwanya kanseri ya paclitaxel

Paclitaxel yakuruye cyane kubera imikorere yayo nuburozi buke bwibikorwa bya antikanseri.Mu bikorwa byo kwa muganga, paclitaxel yagaragaye ko ifite ingaruka zikomeye zo kuvura kanseri zitandukanye, harimo kanseri y'ibere, kanseri y'intanga, kanseri zimwe na zimwe zo mu mutwe no mu ijosi, na kanseri y'ibihaha.Binyuze mu buryo bwihariye bw’ibinyabuzima, paclitaxel irashobora guhagarika neza ikwirakwizwa ry’uturemangingo twa kanseri kandi igatera apoptose ya selile.Byongeye kandi, ibikorwa byo kurwanya kanseri ya paclitaxel nabyo bifitanye isano nubushobozi bwayo bwo kugenzura ubudahangarwa bw'umubiri w'uturemangingo.

Ubushobozi buke bwa paclitaxel

Nubwo paclitaxel ifite ibikorwa bikomeye byo kurwanya antikanseri, ubukene bwayo bwagabanije gukoresha amavuriro.Paclitaxel ikurwa cyane mubiti bya pasifike ya pasifika, kandi kubera umutungo kamere muke, umusaruro wa paclitaxel ntushobora gukemura ibibazo byubuvuzi.Kubwibyo, gushakisha amasoko mashya ya paclitaxel, nko gukora paclitaxel na biosynthesis cyangwa synthesis ya chimique, nibyo byibandwaho mubushakashatsi bwubu.

umwanzuro

Nkumuti usanzwe urwanya antikanseri,paclitaxelifite ibiranga imikorere ihanitse, uburozi buke nubunini bugari, hamwe nuburyo bwihariye bwibinyabuzima bwibikorwa nibikorwa bya anticancer bigira imiti ikomeye yo kuvura kanseri mubikorwa byubuvuzi.Ariko, kubera ubukene bwibikoresho byayo, ikoreshwa ryayo mubikorwa byubuvuzi ni bike.Kubwibyo, ubushakashatsi buzaza bugomba kwibanda ku gushakisha amasoko mashya ya paclitaxel kugira ngo ihuze ibyifuzo by’amavuriro kandi itange uburyo bwinshi bwo kuvura abarwayi ba kanseri.

Icyitonderwa: Inyungu zishobora gukoreshwa muri iyi ngingo zikomoka mubitabo byatangajwe.