Uburyo bwo kubyaza umusaruro Paclitaxel, imiti ikoreshwa cyane mu kuvura kanseri, ni inzira igoye kandi ihanitse ikubiyemo intambwe nyinshi, kuva mu kuvana ahantu nyaburanga kugeza ku miti ya nyuma y’imiti.Uru rupapuro ruzerekana uburyo bwo gukorapaclitaxel, kuva gukuramo kugeza kwitegura.
Intambwe ya 1: Gukuramo
Yamazakiyabanje gukurwa mubishishwa byigiti cya pasifika yew, Pacus pacifica.Inzira itangirana no gukusanya ibishishwa kandi mubisanzwe bisaba gufata neza kugirango wirinde kwangiza igiti.Ibikoresho byakusanyirijwe hamwe noneho bimeneka bigashyirwa mubisubizo bikwiye, nka ether cyangwa xylene.Paclitaxel yasheshwe mukibabi ikaboneka muri iyi ntambwe kugirango ikore extrait.
Intambwe ya 2: Gutandukana
Ibikuramo akenshi birimo ibintu bitandukanye bitandukanye, paclitaxel rero igomba gutandukana nibindi bikoresho.Iyi ntambwe mubisanzwe ikoresha chromatografi ya chromatografiya cyangwa ubundi buryo bwo gutandukanya gutandukanya paclitaxel nibindi bintu bishingiye kumiterere yikigo.
Intambwe ya 3: Kwezwa
Paclitaxel yatandukanijwe igomba kurushaho kwezwa kugirango ikureho umwanda wose usigaye no kubona ibicuruzwa byiza cyane.Ibi mubisanzwe birimo intambwe nko korohereza, kuyungurura, no kongera gukora kugirango tumenye neza ko paclitaxel yanyuma ifite isuku ryinshi.
Intambwe ya 4: Synthesis (bidashoboka)
Nubwo paclitaxel yumwimerere yakuwe mumasoko karemano, ibigo byinshi bikorerwamo ibya farumasi byateje imbere uburyo bwo kubihuza.Ubu buryo bukoresha inzira yimiti yubukorikori kugirango yongere umusaruro no kugenzura no kugabanya gushingira kumutungo kamere.
Intambwe ya 5: Tegura ibiyobyabwenge
Intambwe yanyuma mubikorwa byo kubyaza umusaruro ni ugutegura paclitaxel isukuye mukwitegura gukoreshwa mubuvuzi.Ibi birashobora gushiramo paclitaxel mumashanyarazi akwiye, nka alcool cyangwa ether, kugirango uyitegure mugutegura imiti.Ifishi isanzwe itegurwa nkigisubizo cyatewe kugirango tumenye neza.
Ufatiye hamwe, inzira yo kubyara yapaclitaxelni inzira igoye kandi yintambwe nyinshi yagenewe kwemeza isuku no kugenzura ibiyobyabwenge byanyuma.Intsinzi yiyi nzira ni ingenzi mu gutanga imiti ivura kanseri bityo ikaba ihora itezwa imbere kandi igashyirwa mu bikorwa kugira ngo ivure ibikenewe mu buvuzi.
Icyitonderwa: Inyungu zishobora gukoreshwa muri iyi ngingo zikomoka mubitabo byatangajwe.
Yunnan Hande Biotechnology Co., Ltd yibanze ku musaruro wa paclitaxel mu myaka 26, kandi ni uruganda rwigenga rukora imiti ikuramo imiti irwanya kanseri paclitaxel API yemejwe na Amerika FDA, Uburayi EDQM, Ositaraliya TGA, Ubushinwa CFDA , Ubuhinde, Ubuyapani n’izindi nzego zishinzwe kugenzura igihugu.Yunnan Hande paclitaxel, gutanga isoko, kugurisha uruganda rutaziguye, urakaza neza kubaza, 18187887160 (WhatsApp numero imwe)
Igihe cyo kohereza: Ukwakira-13-2023