Paclitaxel nigicuruzwa gisanzwe cyakuwe mubishishwa byigiti cya pasifika ya pasifika (Taxus pacifica) .Biyosintezisi ya paclitaxel ikubiyemo inzira igoye ya biosynetike, harimo enzymes nyinshi hamwe nabahuza.Nubwo inzira yuzuye ya synthesis ya paclitaxel yarigishijwe, iracyakomeza bigoye mubikorwa nyabyo byinganda.Dore muri rusange muri rusange paclitaxel biosynthesis:
1.Gutangira ibikoresho: Biosynthesis ya paclitaxel itangirana nibintu bisanzwe bitangira, mubisanzwe biva mumababi cyangwa igishishwa cyigiti cya yew.Ibikoresho byo gutangira birimo ibice byababyeyi bishobora gukoreshwa muguhuza ababanjirije paclitaxel.
2.Multi-enzyme catalizike: Biosynthesis yapaclitaxelbisaba imisemburo myinshi kugirango ihagarike reaction.Iyi misemburo ihindura ibintu bitangira mubahuza bigenda bihinduranya buhoro buhoro paclitaxel ya molekile ibanziriza.
3.Synthesis yumuhuza: Abahuza nintambwe yingenzi muguhuza paclitaxel.Bigizwe nibintu byinshi bya polycyclic hamwe nuruhererekane rwuruhererekane bigenda bihinduranya buhoro buhoro binyuze murukurikirane rwa enzyme-catalizike.
4. Synthesis yanyuma ya paclitaxel: molekules zibanza kugirango synthesis ya paclitaxel ihindurwe buhoro buhoro muri molekile ya paclitaxel mu ntambwe nyinshi zifatika.Iyi myitwarire irimo synthesis ya polycyclic, acylation, deketone, nizindi ntambwe zingenzi.
5.Gukuramo no kwezwa: Nyuma ya synthesis ya paclitaxel, intambwe yo gukuramo no kweza irasabwa gutandukanya paclitaxel yera nuruvange rwa reaction.
Nubwo inzira karemano ya biosynetike yapaclitaxelbyakozweho ubushakashatsi, umusaruro nyawo wa paclitaxel ukomeje kuba ingorabahizi kuko bisaba synthesis igoye hamwe nintambwe nyinshi hamwe n’ibikoresho byinshi bibisi. Kubera izo mbogamizi, abahanga banakoze ubushakashatsi ku nzira y’ubukorikori kugira ngo bahuze paclitaxel mu rwego rwo kongera umusaruro no kuboneka.Sintetike synthesis ya paclitaxel mubisanzwe ikubiyemo inzira yoroshye yo guhuza inzira kugirango igabanye ingorane.
Icyitonderwa: Inyungu zishobora gukoreshwa muri iyi ngingo zikomoka mubitabo byatangajwe.
Yunnan Hande Biotechnology Co., Ltd.yibanze ku musaruro wa paclitaxel mu gihe cy’imyaka 26, kandi ni uruganda rwigenga rukora ibimera bivanwa mu bimera bivura kanseri paclitaxel API byemejwe na Amerika FDA, EDQM y’Uburayi, Ositaraliya TGA, Ubushinwa CFDA , Ubuhinde, Ubuyapani nizindi nzego zishinzwe kugenzura igihugu.Yunnan Hande paclitaxel, gutanga isoko, kugurisha uruganda mu buryo butaziguye, ikaze kubaza, 18187887160 (WhatsApp numero imwe)
Igihe cyo kohereza: Ukwakira-12-2023