Kunyura munzira ya synthesis ya paclitaxel

Paclitaxel ni metabolite isanzwe ya kabiri yitaruye kandi yezwa mubishishwa byumuriro utukura.Byaragaragaye ko bifite ingaruka nziza zo kurwanya ibibyimba, cyane cyane kuri kanseri yintanga, nyababyeyi na kanseri y'ibere, bifite kanseri nyinshi.Kugeza ubu,paclitaxelna kimwe cya kabiri cyogukora paclitaxel iraboneka kumasoko.Ingingo ikurikira izakunyura munzira ya synthesis ya paclitaxel.

Yamazakiikurwa mu kibabi n'amababi y'iki gihingwa, kandi inzira yo kuyikuramo iragoye cyane, idashobora gushonga mu mazi n'inzoga, kandi ibirimo ni bike cyane, 100g gusa, ni ukuvuga imirizo ibiri ya paclitaxel, irashobora gukurwa muri toni 30 z'igishishwa cyumye. .Nubwo synthèse yimiti yose yarangiye muri laboratoire, ikubiyemo inzira nyinshi, imiterere ikaze, igiciro kinini numusaruro muke.Kubwibyo, ntibishoboka kuyibyaza umusaruro munganda hamwe na synthesis yimiti yose, bigatuma bihenze cyane.

Kuva bisanzwepaclitaxelikurwa muri pasifike yew, ikaba isoko idasanzwe, kandi imikurire yikura rya yew karemano ni ndende, hafi kg 13,6 yikibabi kugirango ikuremo garama 1 ya paclitaxel, nibiti 3-12 byera hejuru yimyaka 100 birasabwa kuvura intanga imwe. umurwayi wa kanseri, gutanga igihe kirekire nigiciro kinini byatumye iterambere ryihuta ryikoranabuhanga rya sintetike ya paclitaxel.

Kugeza ubu, uburyo nyamukuru bwa synthesis ya paclitaxel nuburyo bwa bioengineering, nabwo buzwi nka paclitaxel semisynthesis.Uburyo bwa bioengineering bukoreshwa mukubyara paclitaxel murwego runini mu korora no gusuzuma amoko ashobora kubyara paclitaxel nyinshi, hanyuma mugukomeza kubihingamo, guhindura no guhindura imiterere yimiterere yabyo, paclitaxel irashobora gukorerwa muburyo bwumuco “nta kugarukira ”, kandi ntibikigarukira ku buke bw'ibikoresho fatizo.Ibisubizo byubushakashatsi buheruka kwerekana byerekana ko imikorere ya synthesis yazamutse cyane kubera umusaruro mwinshi wa microgramo 448.52 za ​​paclitaxel kuri litiro yumuco.

Sintezike yimiti, nubwo yarangiye, ntabwo ijyanye ninganda bitewe nuburyo bukomeye busabwa, umusaruro muke, nigiciro kinini.Uburyo bwa sintetike ya paclitaxel ubu irakuze kandi ifatwa nkuburyo bwiza bwo kwagura isoko ya paclitaxel uretse guhinga.Uburyo bwa kimwe cya kabiri kirashobora gukoresha cyane umutungo wibimera.

Icyitonderwa: Ibishobora gukorwa hamwe nibisabwa bikubiye muriyi mpapuro bitangwa mubitabo byasohotse.

Gusoma kwagutse:Yunnan Hande Biotechnology Co., Ltd. imaze imyaka 28 yibanda ku musaruro wa paclitaxel.Nicyo gihugu cya mbere cyigenga ku isi gikora imiti ikomoka ku bimera paclitaxel ikomoka ku bimera byemejwe na FDA yo muri Amerika, EDQM yo mu Burayi, TGA yo muri Ositaraliya, Ubushinwa CFDA, Ubuhinde, Ubuyapani n’izindi nzego zishinzwe kugenzura igihugu.uruganda.Niba ushaka kuguraYamazaki API, nyamuneka twandikire kumurongo.