Iterambere rya paclitaxel ninkuru yuzuye impinduramatwara nibibazo, byatangiranye no kuvumbura ibintu bikora muri tagisi ya tagisi, byanyuze mu myaka mirongo yubushakashatsi niterambere, amaherezo biba imiti ikoreshwa cyane mubitaro.
Mu myaka ya za 1960, Ikigo cy’igihugu gishinzwe kanseri na Minisiteri y’ubuhinzi muri Amerika bafatanyije muri gahunda yo gusuzuma ibimera kugira ngo babone imiti mishya ya kanseri.Mu 1962, Barclay, umuhanga mu bimera, yakusanyije ibishishwa n'amababi ava muri leta ya Washington maze abyohereza muri NCI kugira ngo bapimwe ibikorwa byo kurwanya kanseri.Nyuma yubushakashatsi bwakozwe, itsinda riyobowe na Dr. Wall na Dr. Wani amaherezo ryatandukanije paclitaxel mu 1966.
Ivumburwa rya paclitaxel ryashimishije abantu benshi kandi ritangira ubushakashatsi bunini niterambere.Mu myaka yakurikiyeho, abahanga bakoze ubushakashatsi bwimbitse ku miterere y’imiti ya paclitaxel maze bamenya imiterere ya molekile igoye.Mu 1971, itsinda rya Dr. Wani ryongeye kumenya imiterere ya kristu na NMR spectroscopy yapaclitaxel, gushiraho urufatiro rwo gukoresha amavuriro.
Paclitaxel yitwaye neza mu bigeragezo byo kwa muganga kandi abaye umurongo wa mbere wa kanseri y'ibere na ovaire na kanseri zimwe na zimwe zo mu mutwe, mu ijosi no mu bihaha.Nyamara, ibikoresho bya paclitaxel ni bike cyane, bigabanya imikoreshereze yagutse yubuvuzi.Kugirango iki kibazo gikemuke, abahanga bakoze ubushakashatsi bwinshi kugirango bashakishe synthesis ya paclitaxel.Nyuma yimyaka myinshi yimbaraga, abantu bakoze uburyo butandukanye bwo guhuza paclitaxel, harimo synthesis yose hamwe na kimwe cya kabiri.
Mugihe kizaza, ubushakashatsi bwapaclitaxelbizakomeza kuba byimbitse.Hamwe niterambere ryiterambere rya siyanse nikoranabuhanga, abantu bategerejweho kuvumbura ibintu byinshi bioaktique bijyanye na paclitaxel kandi bakarushaho gusobanukirwa nuburyo bwibikorwa.Muri icyo gihe, hamwe niterambere rihoraho ryikoranabuhanga rya synthesis, synthesis ya paclitaxel izarushaho gukora neza kandi yangiza ibidukikije, kugirango itange garanti nziza kubikorwa byayo byubuvuzi.Byongeye kandi, abahanga bazasuzuma kandi ikoreshwa rya paclitaxel ifatanije n’indi miti irwanya kanseri kugira ngo batange uburyo bunoze bwo kuvura.
Muri make,paclitaxelni imiti isanzwe ya anticancer ifite agaciro gakomeye k’ubuvuzi, kandi ubushakashatsi niterambere ryayo byuzuyemo ibibazo nibyagezweho.Mu bihe biri imbere, hamwe n’iterambere rya siyansi n’ikoranabuhanga rikomeje ndetse n’ubushakashatsi bwimbitse, biteganijwe ko paclitaxel izagira uruhare runini mu kuvura ubwoko bwa kanseri.
Icyitonderwa: Inyungu zishobora gukoreshwa muri iyi ngingo zikomoka mubitabo byatangajwe.
Igihe cyo kohereza: Ugushyingo-13-2023