Imiti ya Paclitaxel yafashwe nk'umurongo wa mbere uvura kanseri y'ibere, kandi ikoreshwa cyane mu buvuzi kuri kanseri y'intanga, kanseri y'ibihaha, ibibyimba byo mu mutwe no mu ijosi, kanseri ya oesophageal, kanseri yo mu gifu na sarcoma yoroheje.Mu myaka yashize, binyuze mubushakashatsi bwakomeje kumiti ya paclitaxel no gukomeza kunoza uburyo bwo kuyikora, iyi miti ubu irimo inshinge za paclitaxel, docetaxel (docetaxel), liposomal paclitaxel na paclitaxel ya alubumu.Ni irihe tandukaniro riri hagati yibi biyobyabwenge bya paclitaxel, reka twige byinshi kuri byo hepfo.
I. Itandukaniro mumikorere yibanze
1. Gutera Paclitaxel: Byerekanwe kumurongo wa mbere no gukurikirana ubuvuzi bwa kanseri yintanga igenda itera imbere, kuvura kanseri y'ibere ya lymph node-positif nyuma yuburyo busanzwe bwa adriamycin irimo chimiotherapie, kanseri y'ibere muri kanseri y'ibere metastatike ko yananiwe guhuza imiti ya chimiotherapie cyangwa yongeye kugaruka mu mezi 6 nyuma ya chimiotherapie yongeyeho, kuvura umurongo wa mbere wa kanseri y'ibihaha itari ntoya, no kuvura umurongo wa kabiri wa kanseri ifitanye isano na kanseri ifitanye isano na kanseri.
2. Docetaxel: Kubuvuzi bwa kanseri yamabere yateye imbere cyangwa metastatike yananiwe mbere ya chimiotherapie;kuvura kanseri yateye imbere cyangwa metastatike itari ntoya ya kanseri y'ibihaha yananiwe na chimiotherapie ishingiye kuri cisplatine.Ifite kandi akamaro kanseri y'igifu na kanseri ya prostate.
3. Liposomal paclitaxel: Irashobora gukoreshwa nka chimiotherapie yo ku murongo wa mbere kuri kanseri yintanga na chimiotherapie yo ku murongo wa mbere mu kuvura kanseri y’intanga ngore, kandi irashobora no gukoreshwa hamwe na cisplatine.Irashobora kandi gukoreshwa mugukurikirana kuvura abarwayi ba kanseri yamabere bavuwe na chimiotherapie isanzwe irimo adriamycine cyangwa mukuvura abarwayi bafite ibibazo.Irashobora kandi gukoreshwa ifatanije na cisplatine nka chimiotherapie yo ku murongo wa mbere ku barwayi bafite kanseri y'ibihaha itari ntoya idashobora kuvurwa no kubagwa cyangwa radiotherapi.
4. Paclitaxel ihujwe na Albumin: yerekanwe kuvura kanseri y'ibere metastatike yananiwe kuvura chimiotherapie cyangwa kanseri y'ibere yagarutse mu mezi 6 nyuma ya chimiotherapie.Keretse niba hari imiti igabanya ubukana, chimiotherapie yabanje igomba kuba irimo anticracycline anticancer agent.
II.Itandukaniro mu mutekano wibiyobyabwenge
1. Paclitaxel: kutagira amazi meza.Muri rusange, inshinge zizongeramo surfactants polyoxyethylene yasimbujwe amavuta ya castor hamwe na Ethanol kugirango hongerwe imbaraga za paclitaxel mumazi, ariko histamine irekurwa mugihe amavuta ya castor asimbuwe na polyoxyethylene yangiritse muri vivo, bikaba bishobora no gutera allergie ikomeye kandi bishobora no kwiyongera. periferique neurotoxicity ya paclitaxel, kandi irashobora no kugira ingaruka ku ikwirakwizwa rya molekile zibiyobyabwenge mu ngingo kandi bikagira ingaruka ku kurwanya ibibyimba.
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3. Liposomal paclitaxel: ibiyobyabwenge bikubiye muri bilayeri imeze nka lipide kugirango bibe vicicles miniature, kandi ibiyobyabwenge bikubiye mubice bya liposomal bitarimo amavuta ya castor ya polyoxyethylene asimburwa na etanol ya anhydrous, bitera reaction ya allergique.Nyamara, ubushakashatsi bwerekanye ko imiti ya paclitaxel ubwayo ishobora no gutera hyperensitivite, ariko ku kigero cyo hasi ugereranije no guterwa paclitaxel.Kugeza ubu, liposomes ya paclitaxel iracyasaba kuvura allergie mbere yo kuyikoresha.
4 bisaba kwitegura mbere yo kuvurwa.
Icyitonderwa: Ubushobozi bushoboka nibisabwa bikubiye muri iki kiganiro byakuwe mubitabo byatangajwe.
Yunnan Hande Biotechnology Co, Ltd yagiye ikora ibijyanye no gukorapaclitaxel APImu myaka irenga 20, kandi ni umwe mu bakora uruganda rwigenga ku isi rwa paclitaxel API, imiti ikomoka ku bimera ikomoka ku kurwanya kanseri, yemejwe na FDA yo muri Amerika, EDQM yo mu Burayi, TGA yo muri Ositaraliya, CFDA y’Ubushinwa, Ubuhinde, Ubuyapani n’izindi nzego zishinzwe kugenzura igihugu. .Hande ntishobora gutanga ubuziranenge gusapaclitaxel ibikoresho fatizo, ariko kandi serivise yo kuzamura tekinike ijyanye no gukora paclitaxel.Kubindi bisobanuro, nyamuneka twandikire kuri 18187887160.
Igihe cyo kohereza: Ukuboza-08-2022