Paclitaxel, uruganda rusanzwe rufite ibikorwa bikomeye byo kurwanya kanseri, rwabaye igice cyingenzi mu kuvura kanseri. Ikintu cyitwa taxol, gikomoka ku gishishwa cy’igiti cyera kandi ni alkaloide ya diterpenoid.Mu myaka mike ishize,paclitaxelyerekanye akamaro gakomeye mu kuvura kanseri zitandukanye, zirimo amabere, intanga ngore, na kanseri yo mu mutwe no mu ijosi no mu bihaha.
Mbere na mbere, ibikorwa byo kurwanya kanseri ya paclitaxel ni byo bintu nyamukuru bigize imiti ya farumasi. Irashobora kugenzura neza imikurire y’uturemangingo tw’ibibyimba kandi ikarinda ikwirakwizwa rya metastasis y’ibibyimba mu guhagarika inzira ya ADNELIQUE bityo bikabuza kwigana ADN.Uburyo bwo kubuza bigerwaho cyane cyane muguhindura tubuline, kwirinda mitito no gutera apoptose.
Mubikorwa byubuvuzi, paclitaxel yakoreshejwe cyane mukuvura kanseri yamabere.Mu guhuriza hamwe, paclitaxel irashobora kuzamura cyane ubuzima bwumurwayi, kugabanya ibibyimba byongera kubaho, no kuzamura imibereho yabarwayi.Mu barwayi barwaye kanseri yintanga, paclitaxel nayo yerekanye imbaraga zikomeye ingaruka zo kuvura.Mu kubuza ADN kwigana ingirabuzimafatizo no gutera apoptose, paclitaxel irashobora kugenzura neza imikurire yikibyimba no kuramba kwabarwayi.
Usibye kanseri y'ibere na ovaire,paclitaxelYagaragaje kandi ibisubizo byiza mu kuvura kanseri zimwe na zimwe zo mu mutwe no mu ijosi na kanseri y'ibihaha. Muri ubwo buryo bwo kuvura ibibyimba, paclitaxel ikoreshwa kenshi hamwe n'indi miti igabanya ubukana kugira ngo igire ingaruka nziza yo kuvura.
Nubwo, nubwo ingaruka zo kuvura paclitaxel ari ingirakamaro, hashobora kubaho ingaruka mbi mugihe cyo gukoresha.Abarwayi barashobora guhura nibimenyetso nko guhagarika igufwa ryamagufwa, umwijima nimpyiko zangirika, reaction ya gastrointestinal, allergie, cyangwa vasculitis nyuma yo gukoresha paclitaxel. Kubera iyo mpamvu, mugihe ukoresheje paclitaxel, birakenewe ko ukurikiranira hafi uko abarwayi bitwara, hamwe nubuvuzi bwihuse kugirango bigabanye ingaruka mbi.
Muri rusange,paclitaxelyagize uruhare runini mu kuvura kanseri kandi ifite akamaro kanini mu kurwanya ibibyimba bitandukanye bibi.Nubwo hari ingaruka zitari nziza, binyuze mu buyobozi bujyanye n'imiti no gukurikirana amavuriro, birashobora kugabanya ingaruka zishobora guterwa no kongera ingaruka zo kuvura. Hamwe no gukomeza iterambere rya siyanse n'ikoranabuhanga hamwe no gusobanukirwa byimbitse ingaruka za farumasi ya paclitaxel n'abashakashatsi, dufite impamvu zo kwizera ko ejo hazaza hazabaho imiti mishya kandi ikora neza ya paclitaxel, izana uburyo bwinshi bwo kuvura n'ibyiringiro kubarwayi ba kanseri.
Icyitonderwa: Inyungu zishobora gukoreshwa muri iyi ngingo zikomoka mubitabo byatangajwe.
Igihe cyo kohereza: Ugushyingo-14-2023