Uruhare rwa paclitaxel ya kimwe cya kabiri

Semi-syntetique paclitaxel ni imiti ikoreshwa cyane mu bikorwa by’ubuvuzi, ikoreshwa cyane mu kuvura kanseri zitandukanye bitewe n’ingaruka zayo zidasanzwe ndetse n’ingaruka mbi z’uburozi. Iyi ngingo izerekana ubumenyi bw’umwuga ku buryo bwo gukora, mu bya farumasi Igikorwa hamwe nubuvuzi bwaigice cya sintetike paclitaxelmu buryo burambuye.

Uburyo bwibikorwa

Uburyo bwibikorwa byaigice cya sintetike paclitaxelni cyane cyane mukubuza polymerisation ya tubuline, gusenya urusobe rwa microtubule selile, bityo bikabuza ikwirakwizwa ryingirabuzimafatizo no gutera apoptose selile. Byongeye kandi, paclitaxel ya sem-syntetique irashobora kandi kugenga ubudahangarwa bw'umubiri w'uturemangingo twibibyimba no kongera ubushobozi bwo kurwanya ibibyimba mumubiri. .

Ingaruka za farumasi

Semi-synthique paclitaxel yerekanye ibikorwa bidasanzwe bya anticancer mubushakashatsi bwa farumasi, kandi igira ingaruka nziza zo kuvura kanseri zitandukanye nka kanseri yamabere, kanseri yintanga na kanseri yibihaha. Ingaruka za anticancer zigaragara cyane mubice bikurikira:

Kubuza ikwirakwizwa ry'utugingo ngengabuzima: paclitaxel igice cya sintetike irashobora kubuza ikwirakwizwa ry'uturemangingo tw’ibibyimba, cyane cyane ku ngirabuzimafatizo ziri mu cyiciro cya mitoto.

Kwinjiza apoptose: paclitaxel igice cya sintetike irashobora gutera apoptose ya selile yibibyimba muguhindura uburyo bwa apoptose ya selile yibibyimba, kugirango tugere ku ntego yo kuvura ibibyimba.

Kongera ubudahangarwa bw'umubiri: paclitaxel igice cya sintetike irashobora kugabanya ubudahangarwa bw'umubiri w'uturemangingo twibibyimba no kongera ubushobozi bwo kurwanya ibibyimba umubiri.

Gusaba ivuriro

Semi-synthique paclitaxel ikoreshwa cyane mubuvuzi bwa kanseri zitandukanye, nka kanseri y'ibere, kanseri yintanga, kanseri y'ibihaha n'ibindi. kanseri zitandukanye.Mu mikoreshereze yubuvuzi, paclitaxel ya-syntetique ikoreshwa kenshi ifatanije nindi miti ya chimiotherapeutique kugirango iteze imbere imiti.

Ingaruka mbi

Ingaruka z'uburozi za paclitaxel igice cya sintetike ni nkeya, ariko irashobora gutera ingaruka mbi zimwe na zimwe, nka anaphylaxis, guhagarika amagufwa, uburozi bwumutima, nibindi.Mu mavuriro, umuganga azahindura urugero ninshuro zibiyobyabwenge ukurikije imiterere yihariye yumurwayi no kwihanganira imiti kugirango hagabanuke ingaruka ziterwa nuburozi kumurwayi.

Iterambere ry'ejo hazaza

Hamwe niterambere ryiterambere rya siyanse nikoranabuhanga hamwe n’ubushakashatsi bwimbitse kuri paclitaxel, ubushakashatsi buzaza kuri paclitaxel ya santetike ya santetike buzaba bwagutse kandi bwimbitse. Usibye gukomeza gushakisha uburyo bwibikorwa byo kurwanya kanseri, kurushaho ubushakashatsi buzakorwa muburyo bwo kunoza uburyo bwo kuvura paclitaxel ya sem-syntetique no kugabanya ingaruka zayo zifite ubumara.Muri icyo gihe, hamwe n’iterambere ry’ikoranabuhanga rigenda ryiyongera nka injeniyeri ya geneti n’ubuvuzi bw’akagari, ingamba zo kuvura zihariye za paclitaxel bizanashoboka, guha abarwayi ba kanseri uburyo bwiza kandi bwiza bwo kuvura.

Umwanzuro

Nkumuti wingenzi urwanya antikanseri,igice cya sintetike paclitaxelIfite uburyo butandukanye bwo kuvura.Ni ingaruka zikomeye zo kuvura hamwe ningaruka nkeya zifite uburozi butuma iba imwe mumahitamo yingenzi yo kuvura kanseri nyinshi.Mu gihe kizaza, ubushakashatsi kuri paclitaxel ya sem-syntetique buzaba bwimbitse kandi byuzuye, bitanga uburyo bwiza bwo kuvura nibyiringiro byo kubaho kubarwayi ba kanseri.

Icyitonderwa: Inyungu zishobora gukoreshwa muri iyi ngingo zikomoka mubitabo byatangajwe.