Gukoresha Paclitaxel mubikoresho byubuvuzi

Paclitaxel, ibicuruzwa bisanzwe byakuwe mu muriro utukura, birinda indwara ya selile yibibyimba ikora kuri poroteyine za microtubule.Ni umuntu uhagarariye icyiciro cya paclitaxel kandi niwo muti wa mbere w’imiti ukomoka ku gihingwa karemano wakiriye icyemezo cya FDA cyo kuvura kanseri zitandukanye, zirimo intanga ngore, amabere, ibihaha, sarcoma ya Kaposi, kanseri y'inkondo y'umura na kanseri.Mu myaka yashize,paclitaxelyanamamaye cyane kubera gukoresha ibikoresho byubuvuzi.Reka tubirebe mu ngingo ikurikira.

Imikoreshereze yapaclitaxelmu bikoresho by'ubuvuzi

Paclitaxel, binyuze muri polymerisation icyarimwe hamwe na α (α-tubulin) na β (β-tubuline) ya microtubuline, itera microtubules nyinshi ya polymerize idasanzwe, bikavamo ihinduka ryimiterere ya skeletale ya selile no gutakaza imikorere isanzwe, gutera iterambere ry'utugingo guhagarara mu cyiciro cya G0 / G1 na G1 na GM, na mitito ya selile ikumirwa mu cyiciro cya mitoto, amaherezo ikagera no kubuza kugabana imitsi yoroshye y'imitsi, gukwirakwira Igisubizo ni ukubuza amacakubiri no gukwirakwira kw'imitsi yoroshye y'imitsi. kandi wirinde restenosis kubaho.

1. Yamazakiibiyobyabwenge

Stent-eluting stent (DES) ni stent ikoresha urubuga rwicyuma rwambaye ubusa kugirango itware (gutwara) imiti igabanya ubukana bwa endoteliyale, irekurwa n’imyororokere y’ibanze mu bwato kugira ngo ihagarike neza ikwirakwizwa rya endoteliyale mu rwego rwo kwirinda indwara ya restenosis muri stent.Gukoresha neza ibiyobyabwenge biva mu biyobyabwenge byagabanije cyane indwara ya restenosis no kongera gutabara, ariko ntibyagabanije umuvuduko w’indwara n’impfu.Nta tandukanyirizo ryibanze ryagaragaye mu bihe by’amavuriro hagati y’ibiyobyabwenge biva mu biyobyabwenge, hamwe n’ibice byanyuma byunguka.Ibicuruzwa biva mu biyobyabwenge birimo stent yambaye ubusa ikozwe mu byuma bidafite ingese cyangwa cobalt-chromium itwikiriwe n’abatwara imiti igabanya ubukana hamwe n’ibikoresho byoherejwe n’ibiyobyabwenge bya polymeric birimo ibiyobyabwenge bihoraho, biodegradable, na polymer bitarimo ibiyobyabwenge, kandi birimo ibiyobyabwenge birimo limoxylate na paclitaxel.Kugeza ubu, imiti ya paclitaxel ikoreshwa cyane cyane mu kuvura indwara zitandukanye zifata imitsi, imitsi, karotide, impyiko n’umugore.

2. Paclitaxel imipira yuzuye ibiyobyabwenge

Umupira wuzuye ibiyobyabwenge (DCB), nkubuhanga bushya kandi bukuze bwo gutabarana, byagaragaye mubigeragezo byinshi byamavuriro kubera akamaro n’umutekano muri ISR, ibikomere byitwa stenosis intracoronary, ibikomere bito, ibikomere bito, nibindi.

Icyitonderwa: Ingaruka zishoboka nibikorwa byasobanuwe muriyi ngingo biva mubitabo byasohotse.

Gusoma kwagutse:Yunnan Hande Biotechnology Co., Ltd. imaze imyaka 28 yibanda ku musaruro wa paclitaxel.Nicyo gihugu cya mbere cyigenga ku isi gikora imiti ikomoka ku bimera paclitaxel ikomoka ku bimera byemejwe na FDA yo muri Amerika, EDQM yo mu Burayi, TGA yo muri Ositaraliya, Ubushinwa CFDA, Ubuhinde, Ubuyapani n’izindi nzego zishinzwe kugenzura igihugu.uruganda.Niba ushaka kuguraYamazaki API, nyamuneka twandikire kumurongo.