Niki paclitaxel ihujwe na albumin?

Niki paclitaxel ihujwe na albumin?Paclitaxel ihujwe na Albumin (bakunze kwita albumin paclitaxel, nanone mu magambo ahinnye yitwa Nab-P) ni paclitaxel nanoformulation nshya, izwi ku rwego mpuzamahanga nk'imikorere ya paclitaxel.Ihuza alubumu ya endogenous yumuntu hamwe na paclitaxel muburyo budahwitse kandi nanoparticles yavuyemo ikuraho burundu ibibi bya paclitaxel idashonga mumazi, bitabaye ngombwa ko amavuta ya polyoxyethylene cyangwa hagati ya 80 nkumuti umwe.Nka albumin nigicuruzwa gisanzwe cya endogenous, gifite ibyiza byo kuba umutekano, udafite uburozi, udafite ubudahangarwa, ibinyabuzima byangiza, na biocompatible.

Kuki paclitaxel ihujwe na albumin yateye imbere cyane?

1. Nta co-solubilizationno mbere yo kuvura

Kwemeza poroteyine ya plasma ikomoka ku miterere karemano, ihuza molekile ya hydrophobique paclitaxel mu buryo budahuje imbaraga nta na hamwe ishobora gukemura, ikuraho hyperensitivite hamwe n’uburozi bw’uburozi buterwa no gufatira hamwe, bityo bikuraho gukenera imisemburo ya hormone mbere yo kuyikoresha no kugabanya igihe cyo kwinjiza. kugeza ku minota 30, kugabanya cyane ibitaro abarwayi ba oncology, ndetse no kurangiza chimiotherapie binyuze mumavuriro yumunsi.

2. Imiti myiza ya farumasi

Ugereranije na paclitaxel isanzwe, albumin paclitaxel ifite ikwirakwizwa ryihuse kandi ryinshi mu mubiri, ndetse no gusohoka gahoro gahoro, imyenda yihanganira mumubiri wumuntu irashobora kwiyongera cyane kandi ingaruka zo kuvura zikaba nziza cyane.

3. Guhitamo ibibyimba byaho

Imwe mumpamvu zituma abarwayi benshi batinya chimiotherapie ya paclitaxel nuko ikwirakwizwa rya paclitaxel gakondo mumyanya yibibyimba nizindi ngingo zisanzwe ari kimwe, bitera ingaruka nyinshi zikomeye.Ibinyuranye na byo, paclitaxel ifite igitangaza "gutoranya ibibyimba byaho byihitirwa" kandi kwibanda kwayo mubyimba byibibyimba biri hejuru cyane ugereranije nibindi bice bisanzwe.

Icyitonderwa: Ingaruka nibisabwa byasobanuwe muriyi ngingo byakuwe mubitabo byasohotse.

Yunnan Hande Bio-Tech Co, Ltd yagiye ikora ibijyanye no gukorapaclitaxel APIkumyaka irenga 20, kandi numwe mubambere ku isi bakora paclitaxel API byemejwe na FDA, icyemezo cya CEP nicyemezo cya GMP mubushinwa.Hande ntishobora gutanga gusa ubuziranenge bwa paclitaxel API ariko kandi iratangaserivisi yo kohereza ikoranabuhanga kuri paclitaxel albumin.Kubindi bisobanuro, nyamuneka twandikire kuri 18187887160.