Niki paclitaxel, paclitaxel yo guhagarika inshinge na paclitaxel ihujwe na albumin? Ni ubuhe buryo bukoreshwa cyane? Tuzabisobanura muri make muri iki kiganiro.
Ubusanzwe metabolite isanzwe yitaruye kandi isukuye mubishishwa, amashami namababi ya gymnospermous taxus chinensis irashobora guteza imbere polymerisation ya microtubule kandi igahindura microtubules ya polymerized.Ingirabuzimafatizo zanduye paclitaxel zizegeranya microtubule nyinshi muri selile.Kwirundanya kwa microtubules birabangamira. hamwe nibikorwa bitandukanye byutugingo, cyane cyane guhagarika igabana rya selile kuri mitoto, kandi ikabuza kugabana bisanzwe.
Ifite ingaruka nziza zo kurwanya ibibyimba kandi ikoreshwa mu kuvura kanseri y'ibere yateye imbere, kanseri y'ibihaha, kanseri y'intanga, kanseri yo mu mutwe no mu ijosi, kanseri yoroheje y'ingirangingo na kanseri y'ibiryo.
Paclitaxel (Taxol) ni anticancer API (Active Pharmaceutical Ingredient), idashobora gukoreshwa n'abantu mu buryo butaziguye. Igomba gutangwa ku masosiyete yo hasi cyangwa inganda zimiti kugirango ibe imwe muri API yibiyobyabwenge byarangiye.
Kugeza ubu, paclitaxel ikoreshwa cyane ni inshinge za anticancer hamwe n’ibikoresho by’ubuvuzi (harimo na stent na ballon) .Ni iterambere ryihuse ry’ibinyabuzima n’ikoranabuhanga mu buvuzi, ikoreshwa rya paclitaxel naryo rihora rishakishwa, kandi n’uburyo butandukanye bw’abarwayi nabwo bikomeje kunozwa. Emera ko mu gihe cya vuba, bizaba bifite umutekano kandi bizafasha mu kuvura abaganga n’abarwayi, kandi hazabaho ubwoko bwinshi n’imiti myinshi y’imiti igabanya ubukana irimo paclitaxel ifite ingaruka zikomeye za antikanseri.
Paclitaxel yo guhagarika inshinge:
Urushinge rurimo paclitaxel API.
Paclitaxel yo gutera inshinge nayo irimo polyoxyethylene castor yamavuta ya paclitaxel; inshinge ya paclitaxel ya Liposome; inshinge ya paclitaxel ya Albumin; Micellar paclitaxel nubundi buryo bwa dosiye.
Ikoreshwa cyane muri kanseri y'ibere, kanseri y'ibihaha, kanseri y'intanga n'izindi ndwara, kandi ni umwe mu miti igabanya ubukana muri iki gihe.
Albumin Bound Paclitaxel:
Inshinge ya paclitaxel ya Albumin ni imyiteguro ihuza paclitaxel na albumin.Ni iya paclitaxel yo gutera inshinge kandi ni imwe mu inshinge zikoreshwa cyane na paclitaxel n'umutekano mwinshi.
Albumin paclitaxel, uwambere winjiye mumaso yabantu ni Injection ya ABRAXANE (ABRAXANE Kuri Injectable Suspension paclitaxel poroteyine ihujwe na insina zo guhagarika inshinge, alubumu ihujwe) yemejwe na FDA mu 2005, ikoreshwa mu kuvura kanseri y'ibere metastatike. kongera guseswa ni nka 130 nm, kandi ntabwo irimo ibishishwa byuburozi.Ingaruka zumutekano ningaruka zo kuvura birarenze cyane ibyateguwe bisa, kandi birakunzwe cyane.Ni nimwe mumpamvu nyamukuru zubushakashatsi no kwigana by'inganda zikomeye zimiti mugihe kizaza.
Irakoreshwa cyane cyane mukuvura kanseri yamabere metastatike yananiwe kuvura chimiotherapie cyangwa kanseri yamabere isubira mumezi 6 nyuma ya chimiotherapie.
Yunnan Hande Bio-Tech yiyemeje ubushakashatsi & iterambere no kubyaza umusaruropaclitaxel,docetaxel,10-DAB igice cya sintetike paclitaxel, nacabazitaxel. 18187887160）
Igihe cyo kohereza: Gashyantare-09-2023