Glabridin ikomoka ku gihingwa Glycyrrhiza glabra, ibaho gusa mu mizi no mu giti cya Glycyrrhiza glabra (Eurasia), kandi ni cyo gice nyamukuru cya Isoflavone kigizwe na Glycyrrhiza glabra.Glabridinifite umweru, antioxydeant, anti-inflammatory nizindi ngaruka. Bitewe nibintu bike ugereranije na glabridin hamwe ningorabahizi yo kwezwa, ifite izina rya "zahabu yera".
1 principle Ihame ryera rya Glabridin
Mbere yo gusobanukirwa ihame ryera rya glabridin, dukeneye kubanza gusobanukirwa muri make ibitera umusaruro wa melanin.
Synthesis ya melanin isaba ibintu bitatu by'ibanze:
Tyrosine: Ibikoresho nyamukuru byo gukora melanine.
Tyrosinase: igipimo nyamukuru kigabanya enzyme ihindura tirozine muri melanin.
Ubwoko bwa ogisijeni ikora: Tyrosine igomba guhuzwa na ogisijeni mugikorwa cyo gukora melanine ikorwa na Tyrosinase.
Tyrosinase irashobora gutanga melanine buri gihe.Ibitera hanze (harimo imirasire ya ultraviolet isanzwe, gutwika, allergie, nibindi.) Birashobora gutuma umuntu asohoka cyane, biganisha ku mwijima.
Muri icyo gihe, ubwoko bwa ogisijeni ikora (ROS) iterwa n'imirasire ya ultraviolet irashobora kwangiza membrane ya fosifolipide ya tissue y'uruhu, igaragara nka erythema na pigmentation ku ruhu. Kubera iyo mpamvu, ROS ni ikintu gishobora gutera pigmentation kuruhu.Nuko rero, kubuza ibisekuruza byayo birashobora kubuza ibisekuruza bya melanin na pigmentation.
2 ibyiza byo kwera bya Glabridin
Muri make, inzira yo kwera no kumurika ni inzira yo kurwanya Tyrosinase nubwoko bwa ogisijeni ikora.
Glabridin ibuza cyane ibikorwa bya Tyrosinase binyuze mu guhatanira guhuza ibitsina guhatanira, gufata igice cya Tyrosinase kure y’impeta ya catalitiki ya synthesis ya melanin, ikabuza guhuza substrate na Tyrosinase, bityo bikabuza synthesis ya melanin.Mu gihe kimwe,glabridinubwayo ifite antioxydants nziza na anti-inflammatory ingaruka.
Guteranya,glabridincyane cyane ibuza melanogenezi binyuze mu byerekezo bitatu: kubuza ibikorwa bya Tyrosinase, kubuza kubyara amoko ya ogisijeni ikora, no kubuza gutwika.
Ubushakashatsi bwerekanye ko ari ibintu byihuta, bikora neza, kandi byera kandi byera bikuraho amavuta yo kwisiga.Hariho amakuru yubushakashatsi yerekana ko ingaruka zera za Glabridin zikubye inshuro 232 za vitamine C zisanzwe, zikubye inshuro 16 hydroquinone (quinone), na Inshuro 1164 za "arbutin".
Ibisobanuro: Ingaruka zishoboka hamwe nibisabwa byavuzwe muriyi ngingo byose biva mubitabo biboneka kumugaragaro.
Igihe cyo kohereza: Jun-28-2023